Studying the green tea-based radioprotective potential for mice tissue application

Abstract

Ionizing radiation (gamma ray) generates numerous reactive oxygen species (ROS), such as superoxide ( ), hydrogen peroxide ( ), and hydroxyl radicals (OH). These free radicals interact with living cells, causing significant damage and leading to cell death. The aim of this research is to prepare green tea nanoparticles for studying the structural and optical properties of its resulting then use these nanoparticles to protect living rat tissue. The size, shape, and distribution of green tea nanoparticles are characterized by UV-visible absorption spectra, atomic force microscopy (AFM), X-ray diffraction (XRD), and scanning electron microscopy (SEM). Then six groups of mice, part of mice groups are injecting with green tea nanoparticles to study the protected and treated living cells from radiation-induced diseases. By analyzing the histopathological of skin tissue, we conclude that the anti-cancer activity increases with increasing concentrations of green tea nanoparticles and thus, the synthesized nanoparticles are more efficient in biomedical applications in cancer treatment due to their high anti-cancer activity.