Rule of low-level laser therapy (910 nm) in treatment of rheumatoid arthritis: A comparative study between acute and chronic arthritis

Abstract

Rheumatoid arthritis (RA) is a systemic, autoimmune, inflammatory illness of unknown cause that mostly affects synovial joints and surrounding muscle. It causes significant disability and lowers quality of life. This study aims to assess the clinical impact of low-level laser therapy (LLLT 910nm) in acute and chronic phases of RA. In this study, it has been used diode laser 910nm wavelength to treat acute RA and chronic RA. Forty Wister male rats are divided into five experimental groups, with eight rats in each group: group I (Negative control), group II (Positive control acute RA), group III (Positive control chronic RA), group IV (Acute RA +LLLT 910nm), and group V (Chronic RA +LLLT 910nm). RF, IL-6, IL-1β, TNF-α, MDA, SOD is among the biochemical markers associated with rheumatoid arthritis that are evaluated and statistically examined for each group. While the levels of SOD considerably increased in groups IV and V compared to groups II and III, the levels of other biochemical markers (IL-6, IL-1 β, TNF-α, and MDA) significantly decreased (p<0.05). There is non-significant difference in MDA and SOD serum levels between LLLT 910nm treated groups (IV and V) as compared to each other (P=0.236 and P=0.188) respectively. LLLT 910nm effectively reduced inflammation in induced rat model for acute and chronic phases of RA.