Investigating the influence of biosynthetic silver nanoparticles on kidney and tissue function in mice

Abstract

The standard of living and supply innovative nanoparticles solutions to the tests of the present. Owing to their unique properties, such as high conductivity and antibacterial activity, silver nanoparticles (AgNPs) have developed one of the most widely used nanomaterials. Anxieties regarding AgNPs' potential damaging properties on ecosystems and living organisms persevere, nonetheless their benefits. The purpose of this study is to improvement a better understanding of the physiological and histological properties of AgNPs on white Swiss mice by investigative the effects of exposure on behavior organ function, and tissue structure. Staphylococcus aureus strains are used for the creation of AgNPs. For seven and fourteen days, respectively there are two groups of participants are given intraperitoneal injections of 150 mg/kg AgNPs the two groups serving as controls are given sodium chloride solution for the same period of time. Each of the four categories is allocated a different set of twenty-four mice.
The physiological part analyses included testing blood samples for urea, creatinine, and uric acid. Histological analysis is done on kidney tissues to notice the structural changes. Mice injected with AgNPs exhibited a loss of strength, decreased hunger and decreased body weight. Blood urea and creatinine levels are significantly higher in the experimental groups compared to the controls. Histological analysis exposed substantial changes in the kidney tissues including a shrinkage of the glomeruli and an expansion of Bowman's capsule gap these marks of inflammation and necrosis. The best result that Mice injected with 150 mg/kg Ag NPs displayed increased lethargy, introversion, back hunching, and appetite loss. Weight measurements showed significant weight loss after 14 days in the Ag NPs group compared to controls. Physiologically, there are significant increases in urea and creatinine levels in the Ag NPs group after 7 and 14 days, indicating potential kidney damage. Histological analysis revealed a decrease in glomerular diameter and an increase in Bowman's capsule space in the Ag NPs group, further supporting the presence of nephrotoxicity. The study aims to examine the impact of biosynthetic silver nanoparticles on the kidney and tissue function in white Swiss mice. Exactly, the study emphases on investigative phenotypic, behavioral, physiological, and histological changes in mice following exposure to silver nanoparticles, to evaluate potential nephrotoxicity and general health risks related with nanoparticle exposure.